Oxidative Palladium Catalyzed Cross Coupling C-O Bond Formation: Synthesis of Aryl Benzoates

Karmokar, Uttam and G, Satyanarayana (2016) Oxidative Palladium Catalyzed Cross Coupling C-O Bond Formation: Synthesis of Aryl Benzoates. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Esterification is an elementary transformation in the domain of organic chemistry. A facile methodology is presented for palladium catalyzed direct oxidative carboxylation of iodoarenes with benzoic acids. The reaction is successful with catalytic amount of palladium via direct oxidative coupling with benzoic acids in the presence of oxidant (TBHP). The method proceeds with high selectivity and broad substrate scope under mild reaction conditions. Moreover, this catalytic process performed under environmentally benign conditions as water in the TBHP used as the solo reaction medium. Interestingly, this catalytic process showed very good tolerance for many functional groups.

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