Synthesis of platencin core structures via twist-brendane
Khan, Faiz Ahmed and Budanur, B M (2016) Synthesis of platencin core structures via twist-brendane. Arkivoc (2). pp. 206-222. ISSN 1551-7012
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Abstract
The formation of a twist-brendane via intramolecular enolate alkylation is described. Conversion of bicyclo[2.2.1]heptane scaffold present in this twist-brendane through a Grob-type fragmentation to unravel a functionalized bicyclo[2.2.2] system which contains all the necessary carbon atoms of the lipophilic core structure of nor -platencin, a platencin analogue is presented. Synthesis of core structure of platencin was also accomplished by extending this strategy to a starting material possessing a surrogate for the exocyclic methylene group.
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| Item Type: | Article | ||||
| Uncontrolled Keywords: | Enones, Grob-type fragmentation, intramolecular enolate alkylation, twist-brendane, pla tencin | ||||
| Subjects: | Chemistry | ||||
| Divisions: | Department of Chemistry | ||||
| Depositing User: | Team Library | ||||
| Date Deposited: | 28 Mar 2016 04:33 | ||||
| Last Modified: | 21 Sep 2017 06:20 | ||||
| URI: | http://raiithold.iith.ac.in/id/eprint/2251 | ||||
| Publisher URL: | https://doi.org/10.3998/ark.5550190.p009.333 | ||||
| OA policy: | http://www.sherpa.ac.uk/romeo/issn/1551-7012/ | ||||
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