Copper catalyzed coupling of protecting group free and sterically hindered 2-bromobenzyl tertiary alcohols with phenols and anilines: facile synthesis of xanthenes and dihydroacridines

Lodi, M and G, Satyanarayana (2016) Copper catalyzed coupling of protecting group free and sterically hindered 2-bromobenzyl tertiary alcohols with phenols and anilines: facile synthesis of xanthenes and dihydroacridines. RSC Advances, 6 (25). pp. 20588-20597. ISSN 2046-2069

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Abstract

A simple and efficient method for the synthesis of xanthenes and dihydroacridines containing a quaternary carbon atom at the 9th-position, is presented. Significantly, the protocol facilitated the smooth participation of sterically hindered and protecting group free 2-bromobenzyl tertiary alcohols in cross coupling reactions with phenols and anilines, under copper-catalysis. The Lewis acid mediated intramolecular C-C bond formation enabled the formation of a quaternary carbon atom at the 9th-position. Remarkably, this two-step protocol required a single column purification technique.

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IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Domino Palladium Catalysis; Alpha-Mangostin; Trypanothione Reductase; Receptor Antagonists; Xanthone Derivatives; General-Synthesis; K+ Channel; Agents; Acridines; Apoptosis
Subjects: ?? sub5.8 ??
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 18 Mar 2016 05:13
Last Modified: 18 Mar 2016 05:13
URI: http://raiithold.iith.ac.in/id/eprint/2246
Publisher URL: http://dx.doi.org/10.1039/c6ra03447k
OA policy: http://www.sherpa.ac.uk/romeo/issn/2046-2069/
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