Eda, S R and Devarai, Santhosh Kumar and Jinka, Rajeswari
(2015)
Pharmacological and Clinical Importance of Integrin Antagonists in Treatment of Cancer.
Journal of Cell Science and Therapy, 6 (1).
pp. 1-9.
ISSN 2157-7013
Abstract
Integrins are heterodimeric molecules that are composed of 18
α
-subunits and 8
β
-subunits. They exist in 24
distinctive shapes based on combination of these sub-units and are mainly responsible for the adhesion of
extracellular matrix (ECM) and immunoglobulin family molecules. Integrins mediate adhesion of epithelial cells to the
basement membrane and also help in the migration, proliferation and survival of tumor cells. Studies also reveal that
certain integrins act as markers for tumor cells and they also assist in both tumor progression and apoptosis. Studies
reveal that unligated integrins in association with caspase 8 result in inhibition of ECM adhesion might result and
integrin mediated death (IMD) on the other hand integrins in association with oncogenes or receptor tyrosine kinases
can result in enhanced tumorigenesis. Among several types of integrins,
αvβ
3 and
α
5
β
1
have gained importance in
anti-angiogenesis studies
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