Sodium Alginate and Gelatin Hydrogels: Viscosity Effect on Hydrophobic Drug Release
Bhutani, Utkarsh and Laha, A and Mitra, Kishalay and Majumdar, Saptarshi (2016) Sodium Alginate and Gelatin Hydrogels: Viscosity Effect on Hydrophobic Drug Release. Materials Letters, 164. pp. 76-79. ISSN 0167-577X
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Abstract
Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.
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| Item Type: | Article | ||||||
| Additional Information: | The authors acknowledge the support of Indian Institute of Technology Hyderabad, for the research facilities. | ||||||
| Uncontrolled Keywords: | Sodium Alginate; Gelatin; Piperine; Hydrogels; Viscosity; Plasticizer | ||||||
| Subjects: | Chemical Engineering > Biochemical Engineering | ||||||
| Divisions: | Department of Chemical Engineering | ||||||
| Depositing User: | Team Library | ||||||
| Date Deposited: | 02 Nov 2015 07:32 | ||||||
| Last Modified: | 16 Mar 2019 11:23 | ||||||
| URI: | http://raiithold.iith.ac.in/id/eprint/2002 | ||||||
| Publisher URL: | https://doi.org/10.1016/j.matlet.2015.10.114 | ||||||
| OA policy: | http://www.sherpa.ac.uk/romeo/issn/0167-577X/ | ||||||
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