J, Krishna
(2015)
Domino Transformations: Synthesis of 7-Methyl-5H-dibenzo[a,c][7]annulen-5-ones, Bi-aryls,1,3-Dihydroisobenzofurans,Bi-aryl acetylenes via [Pd]-Catalysis.
PhD thesis, Indian Institute of Technology Hyderabad.
Abstract
Constituting a carbon-carbon bond is one of the most fundamental operations in organic synthesis. In general, the synthesis of organic molecules involves a step-wise operation for the construction of individual bonds. These synthetic transformations become more efficient and viable when several bonds are formed in a one-pot fashion and/or in a sequential one-pot manner without isolating the reaction intermediates/intermediate products, such reactions can be called as domino or sequential domino one-pot reactions, respectively. The latter one would be feasible by altering the reaction conditions or by the addition of reagents to promote the subsequent reaction(s) once after the initial step(s) is/are completed. Particularly, the domino processes promoted by [Pd]-catalysis possesses a great potential for elaboration and the development of new synthetic methods that eventually represent a new frontier to conquer in organic chemistry. These domino strategies elaborate the scope of the traditional cross-coupling chemistry due to more efficient and fast construction of molecular complexity from comparatively uncomplicated building blocks. Such transformations are also called as tandem, sequential, cascade, consecutive, iterative, zipper or one-pot (one-flask) reactions and these link several transformations together in a single synthetic operation. Domino reactions have gained wide acceptance due to increase in efficiency of a reaction by decreasing the number of synthetic transformations, the quantity of reagents and solvents used for workup procedures, column chromatography and minimization of waste and energy. Therefore these reactions have their own significance with respect to ecological and economical aspects.
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