Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022

Pati, Falguni (2023) Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022. Alternatives to Laboratory Animals, 51 (4). pp. 263-288. ISSN 0261-1929

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Abstract

Animal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g. pharmacology, pharmacokinetics and pharmacodynamics). However, due to species differences in physiology, metabolism and sensitivity to drugs, the animal models can often fail to replicate the effects of drugs and chemicals in human patients, workers and consumers. Researchers across the globe are increasingly applying the Three Rs principles by employing innovative methods in research and testing. The Three Rs concept focuses on: the replacement of animal models (e.g. with in vitro and in silico models or human studies), on the reduction of the number of animals required to achieve research objectives, and on the refinement of existing experimental practices (e.g. eliminating distress and enhancing animal wellbeing). For the last two years, Oncoseek Bio-Acasta Health, a 3-D cell culture-based cutting-edge translational biotechnology company, has organised an annual International Conference on 3Rs Research and Progress. This series of global conferences aims to bring together researchers with diverse expertise and interests, and provides a platform where they can share and discuss their research to promote practices according to the Three Rs principles. In November 2022, the 3rd international conference, Advances in Animal Models and Cutting-Edge Research in Alternatives, took place at the GITAM University in Vishakhapatnam (AP, India) in a hybrid format (i.e. online and in-person). These conference proceedings provide details of the presentations, which were categorised under five different topic sessions. It also describes a special interactive session on in silico strategies for preclinical research in oncology, which was held at the end of the first day.

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IITH Creators:

IITH Creators	ORCiD
Pati, Falguni	http://orcid.org/0000-0002-3588-1800

Item Type:

Article

Uncontrolled Keywords:

3Rs; animal models; animal-free; drug discovery; microphysiological system; NAMs; new approach methodologies; organ-on-a-chip; organoid; organs-on-chips; replacement; spheroid; Three Rs; tissue microenvironment; Animal Experimentation; Animal Testing Alternatives; Animals; Drug Discovery; Humans; India; Models, Animal; biomaterial; human monoclonal antibody; animal model; animal welfare; animal well-being; Article; computer model; coronavirus disease 2019; cytomegalovirus infection; data analysis; data science; diet; distress syndrome; drug development; drug efficacy; drug interaction; drug metabolism; drug research; drug safety; drug screening; food safety; health hazard; human; in vitro study; laboratory personnel; liver; liver toxicity; malignant neoplasm; NOD SCID gamma mouse; nonhuman; oncology; One Health; organoid; pharmacology; picornavirus infection; reproducibility; retina disease; Severe acute respiratory syndrome coronavirus 2; three dimensional cell culture; treatment response; animal; animal experiment; animal model; animal testing alternative; India

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

20 Jan 2024 12:25

Last Modified:

20 Jan 2024 12:25

URI:

http://raiithold.iith.ac.in/id/eprint/11790