Insight into the Effect of Stabilizers on Anticancer and Antibacterial Activity of AgBiS2 Nanomaterial

Rengan, Aravind Kumar (2023) Insight into the Effect of Stabilizers on Anticancer and Antibacterial Activity of AgBiS2 Nanomaterial. Chemistry - A European Journal, 29 (34). e202203796. ISSN 0947-6539

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Abstract

The near-infrared (NIR) light-absorbing AgBiS2 nanoparticles can be excited by single-wavelength light, which is the primary characteristic of a photo responsive platform. Chemical synthesis of nanomaterials inevitably requires long-chain organic surfactants or polymers to stabilize them in the nano regime. These stabilizing molecules barricade the interaction of nanomaterials with biological cells. We have produced stabilizer-free (sf-AgBiS2) and polymer-coated (PEG-AgBiS2) nanoparticles; and assessed their NIR mediated anticancer and antibacterial activity to evaluate the effect of stabilizers. sf-AgBiS2 showed better antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus) and displayed excellent cytotoxicity against HeLa cells and live 3-D tumour spheroids compared to PEG-AgBiS2 both in presence and absence of NIR radiation. The photothermal therapy (PTT) results illustrated the tumour ablation ability of sf-AgBiS2, which converted light into heat effectively up to 53.3 °C under NIR irradiation. This work demonstrates the importance of synthesizing stabilizer-free nanoparticles to produce safe and highly active PTT agents.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Uncontrolled Keywords:

antibacterial agent; anticancer agent; nanoparticle surface; silver bismuth sulphide; stabilizer freel; Bacteria; Infrared devices; Lanthanum compounds; Nanostructured materials; Organic polymers; Silver compounds; Sulfur compounds; Synthesis (chemical); Tumors; Anti-bacterial activity; Anti-cancer agents; Anticancer activities; Bismuth sulfide; Nanoparticle surface; Near Infrared; Near-infrared; Silver bismuth sulphide; Stabiliser; Stabilizer-free; Anti-Bacterial Agents; HeLa Cells; Humans; Nanoparticles; Phototherapy; Staphylococcus aureus; antiinfective agent; nanoparticle; Bismuth compounds

Subjects:

Others > Pharmacy
Others > Cell Biology
Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

28 Sep 2023 14:39

Last Modified:

28 Sep 2023 14:39

URI:

http://raiithold.iith.ac.in/id/eprint/11725