Hofmeister series: An insight into its application on gelatin and alginate-based dual-drug biomaterial design

Giri, Lopamudra and Majumdar, Saptarshi (2023) Hofmeister series: An insight into its application on gelatin and alginate-based dual-drug biomaterial design. European Polymer Journal, 189. p. 111961. ISSN 0014-3057

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Abstract

Alginate and gelatin are bio-polymers widely used in drug delivery. A range of salts can be used to achieve the required flexibility in biomaterial design. Hofmeister series gives an idea about the behaviour of salts with proteins. However, its application for the design of biomaterials and their specific effect on high-viscosity polymers and polymer mixtures has not quite been explored. Firstly, this work proposes a strategic interaction-based approach for designing a dual-drug ocular biomaterial. Secondly, the impact of different salt anions on gelatin and alginate mixture for the developed protocols is studied by a proposed method of determining shear-dependent general intrinsic viscosity. Thirdly, shear-dependent intrinsic viscosity is used to determine the interaction amongst the polymers in their mixture, which is then correlated to the release profiles and hydrodynamic radii of polymer mixtures. It is observed that Hofmeister anions behave reversely for high-viscosity negatively charged polymers and depends on the charge densities of the anions. For the polyelectrolyte/polyampholyte complex/mixture, the interactions depend on the addition sequence. It is inferred that the kosmotropes are preferred for protocols where salt is added between gelatin and alginate and chaotropes for protocols where salt is added to the gelatin and alginate complex/mixture in terms of release profiles.

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IITH Creators:

IITH Creators	ORCiD
Giri, Lopamudra	http://orcid.org/0000-0002-2352-7919
Majumdar, Saptarshi	http://www.orcid.org/0000-0002-1340-5993

Item Type:

Article

Uncontrolled Keywords:

Alginate; Gelatin; Hofmeister series; Interactions; Salt anions; Controlled drug delivery; Complex mixture; Gelatin; High viscosities; Hofmeister series; Interaction; Intrinsic viscosity; ITS applications; Polymer mixture; Release profiles; Salt anion; Alginate; Drug interactions; Ions; Polyelectrolytes; Salts; Targeted drug delivery; Viscosity

Subjects:

Chemical Engineering
Chemical Engineering > Technology of industrial chemicals

Divisions:

Department of Chemical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

27 Sep 2023 10:51

Last Modified:

27 Sep 2023 10:57

URI:

http://raiithold.iith.ac.in/id/eprint/11705