An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability

Rengan, Aravind Kumar (2023) An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability. Chemistry - An Asian Journal, 18 (9). e202300044. ISSN 1861-4728

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Abstract

We report the photophysical properties, self-assembly and biological evaluation of an isothiazolanthrone-based dye, 7-amino-6H-anthra[9,1-cd]isothiazol-6-one (AAT), which reveals anticancer properties and can be potentially used as dye for monitoring cell viability. The solvent-dependent photophysical studies suggest that the emission of AAT is sensitive to environment polarity due to which interesting changes in the colored emission may be observed owing to the charge transfer (CT) processes. AAT also self-assembles to tree-like branched morphologies and produce, a greenish emission inside the cells when imaged after short interval (15 mins) of incubation while a red fluorescence could be noted after 24 h. Interestingly, AAT also produce differential emission inside mouse normal cells as compared to its cancer cell lines since it possess anticancer activity. The experimental observations were also validated theoretically via computational modeling.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Uncontrolled Keywords:

Anticancer properties; Cell imaging; Charge transfer; Computational modeling; Fluorescent dye; Self-assembly; Animals; Cell Line; Cell Survival; Mice; Solvents; Spectrometry, Fluorescence; Cell culture; Cells; Computation theory; Computerized tomography; Fluorescence; Self assembly; solvent; Anticancer properties; Biological evaluation; Cell imaging; Cell viability; Color changing; Computational modelling; Fluorescent dyes; Photophysical properties; Photophysical studies; Self-assembling; animal; cell line; cell survival; mouse; procedures; spectrofluorometry; Charge transfer

Subjects:

Biomedical Engineering
Biomedical Engineering > Stem cell research

Divisions:

Department of Biomedical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

26 Sep 2023 06:17

Last Modified:

26 Sep 2023 06:17

URI:

http://raiithold.iith.ac.in/id/eprint/11695