Green synthesis of multi-functional carbon dots from medicinal plant leaves for antimicrobial, antioxidant, and bioimaging applications

Rengan, Aravind Kumar (2023) Green synthesis of multi-functional carbon dots from medicinal plant leaves for antimicrobial, antioxidant, and bioimaging applications. Scientific Reports, 13 (1). p. 6371. ISSN 20452322

Text
s41598-023-33652-8.pdf - Published Version
Download (1MB)

Abstract

In this research work, carbon dots (CDs) were synthesized from the renewable leaves of an indigenous medicinal plant by the one-pot sand bath method, Azadirachta indica. The synthesized CDs were characterized for its optical properties using UV–Vis, Fluorescence and Fourier transform infrared (FT-IR) spectrophotometry and for structural properties using dynamic light scattering (DLS), X-ray Diffraction (XRD) and high resolution Transmission electron microscopy (HR-TEM). The synthesized CDs exhibited concentration dependent biocompatibility when tested in mouse fibroblast L929 cell line. The EC50 values of biomedical studies, free radical scavenging activity (13.87 μgmL−1), and total antioxidant capacity (38 μgmL−1) proved CDs were exceptionally good. These CDs showed an appreciable zone of inhibition when examined on four bacterial (two gram-positive and gram-negative) and two fungal strains at minimum concentrations. Cellular internalisation studies performed on human breast cancer cells (MCF 7- bioimaging) revealed the applicability of CDs in bioimaging, wherein the inherent fluorescence of CDs were utilised. Thus, the CDs developed are potential as bioimaging, antioxidants and antimicrobial agents.

[error in script]

IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Uncontrolled Keywords:

Animals; Anti-Infective Agents; Antioxidants; Carbon; Humans; Mice; Plant Leaves; Plants, Medicinal; Quantum Dots; Spectroscopy, Fourier Transform Infrared; antiinfective agent; antioxidant; carbon; quantum dot; animal; chemistry; human; infrared spectroscopy; medicinal plant; mouse; plant leaf

Subjects:

Biomedical Engineering
Biomedical Engineering > Molecular imaging

Divisions:

Department of Biomedical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

12 Sep 2023 09:06

Last Modified:

12 Sep 2023 09:06

URI:

http://raiithold.iith.ac.in/id/eprint/11667