Deaths from undetected COVID-19 infections as a fraction of COVID-19 deaths can be used for early detection of an upcoming epidemic wave

Raghavan, Mohan (2023) Deaths from undetected COVID-19 infections as a fraction of COVID-19 deaths can be used for early detection of an upcoming epidemic wave. PLOS ONE, 18 (3). e0283081. ISSN 1932-6203

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Abstract

With countries across the world facing repeated epidemic waves, it becomes critical to monitor, mitigate and prevent subsequent waves. Common indicators like active case numbers may not be sensitive enough in the presence of systemic inefficiencies like insufficient testing or contact tracing. Test positivity rates are sensitive to testing strategies and cannot estimate the extent of undetected cases. Reproductive numbers estimated from logarithms of new incidences are inaccurate in dynamic scenarios and not sensitive enough to capture changes in efficiencies. Systemic fatigue results in lower testing, inefficient tracing and quarantining thereby precipitating the onset of the epidemic wave. We propose a novel indicator for detecting the slippage of test-trace efficiency based on the number of deaths/hospitalizations resulting from known and hitherto unknown infections. This can also be used to forecast an epidemic wave that is advanced or exacerbated due to a drop in efficiency in situations where the testing has come down drastically and contact tracing is virtually nil as is prevalent currently. Using a modified SEIRD epidemic simulator we show that (i) Ratio of deaths/hospitalizations from an undetected infection to total deaths converges to a measure of systemic test-trace inefficiency. (ii) This index forecasts the slippage in efficiency earlier than other known metrics. (iii) Mitigation triggered by this index helps reduce peak active caseload and eventual deaths. Deaths/hospitalizations accurately track the systemic inefficiencies and detect latent cases. Based on these results we make a strong case that administrations use this metric in the ensemble of indicators. Further, hospitals may need to be mandated to distinctly register deaths/hospitalizations due to previously undetected infections. Thus the proposed metric is an ideal indicator of an epidemic wave that poses the least socio-economic cost while keeping the surveillance robust during periods of pandemic fatigue.

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IITH Creators:

IITH Creators	ORCiD
Raghavan, Mohan	http://www.orcid.org/0000-0002-9196-8193

Item Type:

Article

Uncontrolled Keywords:

Article; clinical assessment tool; convergence time; coronavirus disease 2019; coronavirus disease 2019 death; disease exacerbation; early diagnosis; epidemic; epidemic wave; fatigue; health care cost; health survey; hospitalization; human; inefficiency; latent infection; laxity; medical information; mitigation; modified SEIRD epidemic simulator; mortality; pandemic; performance measurement system; predictive model; probability; sensitivity analysis; socioeconomics; time; transitional care; contact examination; diagnosis; epidemiology; pandemic; procedures; quarantine; Contact Tracing; COVID-19; Humans; Pandemics; Quarantine; SARS-CoV-2

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

24 Aug 2023 09:17

Last Modified:

24 Aug 2023 09:17

URI:

http://raiithold.iith.ac.in/id/eprint/11611