Casein nanoformulations - Potential biomaterials in theranostics

Khatun, Sajmina and Appidi, Tejaswini and Rengan, Aravind Kumar (2022) Casein nanoformulations - Potential biomaterials in theranostics. Food Bioscience, 50 (102200). pp. 1-10. ISSN 2212-4292

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Abstract

Casein is a milk protein emerging as a potential nanosystem for applications in therapy and diagnosis. Casein consists of four major phosphoproteins with their homologous primary amino acid sequences into the following families αs1, αs2, β, and κ-casein. In the aqueous phase, casein forms micelles binding with colloidal calcium phosphate. Biocompatibility, high drug binding/encapsulation capability, potential to cross the blood-brain barrier, and targeted cellular uptake are a few of the properties of casein micelles, enabling their application in therapy. This review discusses various components, properties, and functions of casein phosphoproteins and casein micelles. Application-specific cross-linking mechanisms and different synthesis approaches are also discussed. This review extensively explores casein's structural and functional properties and its biomedical application: targeted drug delivery and tissue engineering. The potential applications of casein-based complexes for treating iron deficiency anaemia and casein-derived peptides for inhibition of neuronal cognitive disorders are also discussed in this review. © 2022 Elsevier Ltd

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Additional Information:

The authors would like to thank MoE IMPRINT (4291), ICMR (No.35/1/2020-GIA/Nano/BMS), DST-Inspire (DST/INSPIRE/04/2015/000377), DST-AMT (DST/TDT/AMT/2017/227), SERB-CRG (CRG/2020/005069) grants, Vasudha foundations, Hyderabad, India. Author SK acknowledges University Grants Commission (UGC), Govt. of India for UGC-JRF fellowship (18-340769), Author TA acknowledges DST, Govt. of India for Inspire fellowship (IF160291).

Uncontrolled Keywords:

Alzheimer's disease; Anticancer drug delivery; Casein micelles; Iron deficiency anaemia; Tissue engineering

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

Ms Palak Jain

Date Deposited:

22 May 2023 09:48

Last Modified:

22 May 2023 09:48