Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone

Bakthadoss, Manickam and Reddy, Tadiparthi Thirupathi and D S, Sharada (2020) Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone. RSC Advances, 10 (52). pp. 31570-31574. ISSN 2046-2069

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Abstract

A site-selective ruthenium-catalyzed keto group assisted C-H bond activation of 2-aryl tetrahydroquinoline (azaflavanone) derivatives has been achieved with a variety of alkenes for the first time. A wide range of substrates was utilized for the synthesis of a wide variety of alkenylated azaflavanones. This simple and efficient protocol provides the C5-substituted azaflavanone derivatives in high yields with a broad range of functional group tolerance. Further, the C5-alkenylated products were converted into substituted 2-aryl quinoline derivatives in good yields. This journal is © The Royal Society of Chemistry.

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IITH Creators:

IITH Creators	ORCiD
D S, Sharada	UNSPECIFIED

Item Type:

Article

Additional Information:

We thank DST-SERB for the financial support (Ref. No.: 2018/ 000930). TTR thanks UGC for the scholarship. We also acknowledge the DST-FIST for the ESI-HRMS facility.

Uncontrolled Keywords:

C-h activation; CH-bond activation; Efficient protocols; High yield; Keto groups; Quinoline derivative; Site selective; Tetrahydroquinoline

Subjects:

Chemistry

Divisions:

Department of Chemistry

Depositing User:

. LibTrainee 2021

Date Deposited:

23 Nov 2022 07:12

Last Modified:

23 Nov 2022 07:12