NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells

Jogdand, Anil and Alvi, Syed Baseeruddin and Rajalakshmi, P.S. and Rengan, Aravind Kumar (2020) NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells. Journal of Photochemistry and Photobiology B: Biology, 208. pp. 1-9. ISSN 1011-1344

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Abstract

Breast cancer is one of the leading causes of mortality in women, worldwide. The average survival rate of patients suffering from advanced breast cancer is about 27% for five years. Photothermal therapy employing biodegradable nanoparticle are extensively researched for enhanced anticancer therapy in breast cancer treatment. In the current study, we report a chitosan based mucoadherant and biodegradable niosome nanoparticle entrapping near infrared (NIR) dye (IR 806) for the treatment of breast cancer. Niosome entrapping IR 806 (NioIR) showed encapsulation efficacy of about 56 ± 2%. The prepared nanoparticles (NioIR) were further coated with chitosan (NioIR-C) to impart mucoadhesive property to the nanosystem. NioIR-C showed minimal degradation following NIR laser irradiation, thus enhancing its photothermal stability. They also exhibited efficient photothermal transduction, when compared with IR 806 dye. NioIR-C were biocompatible when treated with normal cell lines (NIH 3T3 and L929) and showed cytotoxicity towards breast cancer cell lines (MCF-7 and MDA-MB 231). When triggered with NIR laser, NioIR-C showed photothermal cell death (approximately 93%). The presence of chitosan coating on NioIR led to mucoadherence potential that further enhances the therapeutic effect on breast cancer cells when compared with IR 806 dye and NioIR. Thus NioIR-C can be a promising nanosystem for effective treatment of breast cancer using photothermal therapy. © 2020 Elsevier B.V.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Additional Information:

AJ would like to acknowledge the UGC (201516-RGNF-2015-17-SC-MAH-14156). Author SBA would like to thank the CSIR for SRF as financial support (09/1001(004)/2019-EMR-1). RJ would like to acknowledge the UGC (938/(OBC) (CSIR-UGC NET Dec.2016)) for financial support. AKR would like to acknowledge funding agencies DBT-BT/09/IYBA/2015/14, BT-NNT/28/1836/2017, MHRD-IMPRINT-4291, DST-INSPIRE/04/2015/00037 for their generous financial support.

Uncontrolled Keywords:

Breast cancer; Mucoadhesive nanosystem; Niosome,IR 806; Photothermal therapy

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

16 Nov 2022 05:52

Last Modified:

16 Nov 2022 05:52