Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment

Ghosh, Anwesha and Singh, Vijay K. and Singh, Vivek and Basu, Sayan and Pati, Falguni (2022) Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment. MDPI.

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Abstract

The process of corneal wound healing is complex and induces scar formation. Corneal scarring is a leading cause of blindness worldwide. The fibrotic healing of a major ocular wound disrupts the highly organized fibrillar collagen arrangement of the corneal stroma, rendering it opaque. The process of regaining this organized extracellular matrix (ECM) arrangement of the stromal layer to restore corneal transparency is complicated. The surface retention capacity of ocular drugs is poor, and there is a large gap between suitable corneal donors and clinical requirements. Therefore, a more efficient way of treating corneal scarring is needed. The eight major classes of interventions targeted as therapeutic tools for healing scarred corneas include those based on exosomes, targeted gene therapy, microRNAs, recombinant viral vectors, histone deacetylase inhibitors, bioactive molecules, growth factors, and nanotechnology. This review highlights the recent advancements in molecular therapeutics to restore a cornea without scarring. It also provides a scope to overcome the limitations of present studies and perform robust clinical research using these strategies. © 2022 by the authors.

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IITH Creators:

IITH Creators	ORCiD
Pati, Falguni	http://orcid.org/0000-0002-3588-1800

Item Type:

Other

Additional Information:

This work was supported by: the National Natural Science Foundation of China: 32102405, 31801868, and the Natural Science Foundation of Shandong Province: ZR2020QC156, ZR2020QC063. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Uncontrolled Keywords:

bioactive molecules; corneal scar; exosome; molecular therapeutics; nanotechnology; recombinant viral vectors; si/microRNAs

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

03 Nov 2022 11:47

Last Modified:

03 Nov 2022 11:47