Palladium-catalyzed selective α-arylation of ortho -bromoacetophenones

J, Krishna and A, Gopi Krishna Reddy and G, Satyanarayana (2014) Palladium-catalyzed selective α-arylation of ortho -bromoacetophenones. Synthetic Communications, 44 (14). pp. 2103-2111. ISSN 0039-7911

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Abstract

Synthesis of 1-(2-bromophenyl)-2-phenylethanones via an intermolecular Pd-catalyzed α-arylation of 1-(2-bromophenyl)ethanones is presented. The method relies on selective C-H activation (α-arylation) of relatively more reactive external iodo-arenes as coupling partners without affecting the bromo-substituent. Moreover, the scope and generality of the method has been well studied by employing the reaction with iodo-arenes as coupling partners bearing electron-withdrawing, simple, and electron-donating groups on the aromatic ring.

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IITH Creators:	IITH Creators ORCiD G, Satyanarayana UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	1-(2-bromophenyl)ethanones; C-H activation; iodo-arenes; Pd-catalysis; α-Arylation
Subjects:	?? sub5.8 ??
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	02 Dec 2014 09:31
Last Modified:	24 Sep 2015 10:23
URI:	http://raiithold.iith.ac.in/id/eprint/1110
Publisher URL:	http://dx.doi.org/10.1080/00397911.2014.880789
OA policy:	http://www.sherpa.ac.uk/romeo/issn/0039-7911/
Related URLs:	Google Scholar

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