Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells

Das, Punamshree and Mudigunda, Sushma V. and Darabdhara, Gitashree and Boruah, Purna K. and Ghar, Sachin and Rengan, Aravind Kumar and et al, . (2020) Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells. Journal of Photochemistry and Photobiology B: Biology, 212. pp. 1-11. ISSN 1011-1344

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Abstract

Graphene, which is a unique 2D nanomaterials has received widespread attention for photothermal therapy (PTT) application. Here, we have designed the nanocomposite using polydopamine (PDA) functionalized reduced graphene oxide (rGO) nanosheets and bimetallic AuPd nanoparticles (NPs). The bimetallic AuPd nanoparticles decorated PDA functionalized rGO (AuPd-rGO/PDA) nanocomposite is synthesized by simple chemical reduction technique resulting in an average size of AuPd bimetallic nanostructure of 4.18 nm. The photothermal activity of the AuPd-rGO/PDA nanocomposite is explored under the irradiation of near infrared (NIR) laser sources of wavelength 915 nm. The temperature rises nearly 51 ± 3 °C within 3 min of irradiation NIR laser light resulting in the ablation of MDAMB-231 cancer cells up to concentration of 25 μg mL−1 of AuPd-rGO/PDA nanocomposite. This high performance of the ablation of cancer cells by photothermal therapy technique was facilitated using a low concentration of the nanocomposite by the synergistic effects of the bimetallic AuPd as well as rGO and PDA functionalization. The AuPd-rGO/PDA nanocomposite demonstrated the high biocompatibility towards normal healthy cell lines (L929) and exhibits survival efficiency of more than 85%. We also demonstrated the biocompatibility of the AuPd-rGO/PDA nanocomposite materials on the zebrafish embryos (Danio rerio). This work thus illustrates that the AuPd-rGO/PDA nanocomposite could behave as favourable nanoplatform for tumor therapeutics. © 2020 Elsevier B.V.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Additional Information:

The authors are thankful to the Director, CSIR-NEIST, Jorhat for his support and interest to carry out the work. Authors acknowledge Department of Biotechnology, Govt. of India for financial support (BT/PR16740/NER/95/270/2015, NEIST Project No. GPP 316). PKB is thankful to the CSIR, New Delhi, India, for CSIR-SRF Fellowship. Author SG would like to thank DST, Govt. of India for Inspire fellowship (IF180295). Authors are also recognizing the sophisticated analytical facility of CSIR-NEIST, Jorhat, Assam, India.

Uncontrolled Keywords:

AuPd bimetallic nanoparticles; Biocompatibility; Photothermal therapy; Polydopamine; Reduced graphene oxide

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

26 Oct 2022 11:42

Last Modified:

26 Oct 2022 11:42