Aptamer-Mediated Nanotheranostics for Cancer Treatment: A Review

Ravichandran, Gayathri and Rengan, Aravind Kumar (2020) Aptamer-Mediated Nanotheranostics for Cancer Treatment: A Review. American Chemical Society.

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Abstract

The incessant transitions occurring in a cancer cell in response to cancer therapy have put forth a lot of irreversible consequences, eventuating a high mortality rate. This upsurge in morbidity and fatality is rationalized by the unilateral modes of conventional treatment regimens such as chemotherapy and radiation therapy. Eventually, the advent of nanotechnology in cancer medicine has unfolded a plethora of efficient ways to tackle the impediments associated with current treatment modalities such as metastasis, relapse, and therapy resistance. Active targeting guides nanocarriers for not just mitigating the drug payload but also minimizing the off-target side effects. Nanotherapeutics emphasizes this multidimensional approach and has portrayed promising preclinical outcomes, but clinical assessments need yet to be validated. This review discusses and elaborates on the oligonucleotide aptamer−nanoparticles leveraging active targeting and its applications in multifarious therapeutic interventions for the eradication of cancer. This, in combination with the various technological gains in aptamer synthesis, projects its potential contribution in the facet of nanomedicine. © 2020 American Chemical Society

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	http://orcid.org/0000-0003-3994-6760

Item Type:

Other

Additional Information:

The authors thank the MHRD IMPRINT (Grant 4291), DBT-IYBA (Grant BT/09/IYBA/2015/14), DST-Inspire (Grant DST/INSPIRE/04/2015/000377), DBT-NER (Grant BT/ PRI 16740/40/NER/95/270/2015), and DBT-NBT (Grant BT/PR26700/NNT/28/1386/2017). G.R. thanks the MHRD for an institute fellowship.

Uncontrolled Keywords:

Active targeting; Aptamers; Cancer nanomedicine; Nanoparticles; Nanotheranostics; SELEX

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

26 Oct 2022 09:24

Last Modified:

26 Oct 2022 09:24