A low-cost and miniaturized electrochemical cell for low-sample analyses

Vishnu, Nandimalla and Sharma, Chandra Shekhar and Senthil Kumar, Annamalai (2020) A low-cost and miniaturized electrochemical cell for low-sample analyses. Microchemical Journal, 159. pp. 1-7. ISSN 0026-265X

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Abstract

Most of the conventional electrochemical cells require a minimum sample volume of 2–5 mL for the analyses. However most of the times, availability of biological sample in this much quantity is challenging and may be the reason for misreading. Besides, a lower volume cell is always preferred for analyzing rare or expensive materials. Thus, development of a miniaturized electrochemical cell setup (MECS) with a lower volume capacity at an affordable cost is a paramount of interest. In this present work, a home-made MECS is developed using a disposable graduated microcentrifuge tube vial as a low-volume (150 μL) holding electrochemical cell and 0.7 mm HB-pencil graphite electrode (PGE), Ag wire and PGE as working, reference and counter electrode respectively. These three electrodes are fused into the disposable graduated microcentrifuge tube vial. In our preliminary investigations, kinetic parameters and electro-catalytic response of uric acid (UA) on working electrode (PGE* = predanodized PGE) was demonstrated as a model system for the application of this newly developed MECS. Furthermore, the developed electroanalytical approach was validated by testing the concentration of UA in non-invasive bio-samples (urine and saliva) with an electrode recovery value of ~ 100%. © 2020 Elsevier B.V.

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IITH Creators:

IITH Creators	ORCiD
Sharma, Chandra Shekhar	https://orcid.org/0000-0003-3821-1471

Item Type:

Article

Additional Information:

The authors acknowledge the support from GITAM (deemed-to-be University), MHRD-ICMR supported IMPRINT project 8058 and Department of Science and Technology-Technology Development Program funded project (DST/IDP/MED/04/2017).

Uncontrolled Keywords:

Electrochemical cell; Low-volume; Microcentrifuge tube vial; Pencil graphite; Uric acid

Subjects:

Chemical Engineering

Divisions:

Department of Chemical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

22 Oct 2022 06:59

Last Modified:

22 Oct 2022 06:59