The role of gut microbiota in the development of colorectal cancer: a review

Koyande, Navami and Gangopadhyay, Madhusree and Thatikonda, Shashidhar and Rengan, Aravind Kumar (2022) The role of gut microbiota in the development of colorectal cancer: a review. Springer.

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Abstract

Purpose: Colorectal cancer (CRC) is the cancer of the colon and rectum. Recent research has found a link between CRC and human gut microbiota. This review explores the effect of gut microbiota on colorectal carcinogenesis and the development of chemoresistance. Methods: A literature overview was performed to identify the gut microbiota species that showed altered abundance in CRC patients and the mechanisms by which some of them aid in the development of chemoresistance. Results: Types of gut microbiota present and methods of analyzing them were discussed. We observed that numerous microbiota showed altered abundance in CRC patients and could act as a biomarker for CRC diagnosis and treatment. Further, it was demonstrated that microbes also have a role in the development of chemoresistance by mechanisms like immune system activation, drug modification, and autophagy modulation. Finally, the key issue of the growing global problem of antimicrobial resistance and its relationship with CRC was highlighted. Conclusion: This review discussed the role of gut microbiota dysbiosis on colorectal cancer progression and the development of chemoresistance. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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IITH Creators:

IITH Creators	ORCiD
Thatikonda, Shashidhar	https://orcid.org/0000-0003-2973-2224
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Other

Additional Information:

The study was supported by the Indo-UK project entitled “AMRflows UK-India project: antimicrobials and resistance from manufacturing flows to people: joined up experiments, mathematical modelling and risk analysis” (AMRflows; grant number DBT/CE/F064/2020–21/G307) funded by the Department of Biotechnology (Government of India).

Uncontrolled Keywords:

Antimicrobial resistance; Chemoresistance; Colorectal cancer; Dysbiosis; Gut bacteria

Subjects:

Biomedical Engineering
Civil Engineering

Divisions:

Department of Biomedical Engineering
Department of Civil Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

18 Oct 2022 07:26

Last Modified:

18 Oct 2022 07:26