Microfluidic Biosensor-Based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis

Sukanya, V. S. and Rath, Subha Narayan (2022) Microfluidic Biosensor-Based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis. In: Microfluidics and Biosensors in Cancer Research. Springer, pp. 319-339.

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Abstract

Breast cancer with unpredictable metastatic recurrence is the leading cause of cancer-related mortality. Early cancer detection and optimized therapy are the principal determining factors for increased survival rate. Worldwide, researchers and clinicians are in search of efficient strategies for the timely management of cancer progression. Efficient preclinical models provide information on cancer initiation, malignancy progression, relapse, and drug efficacy. The distinct histopathological features and clinical heterogeneity allows no single model to mimic breast tumor. However, engineering three-dimensional (3D) in vitro models incorporating cells and biophysical cues using a combination of organoid culture, 3D printing, and microfluidic technology could recapitulate the tumor microenvironment. These models serve to be preferable predictive models bridging the translational research gap in drug development. Microfluidic device is a cost-effective advanced in vitro model for cancer research, diagnosis, and drug assay under physiologically relevant conditions. Integrating a biosensor with microfluidics allows rapid real-time analytical validation to provide highly sensitive, specific, reproducible, and reliable outcomes. In this manner, the multi-system approach in identifying biomarkers associated with cancer facilitates early detection, therapeutic window optimization, and post-treatment evaluation. This chapter showcases the advancements related to in vitro breast cancer metastasis models focusing on microfluidic devices. The chapter aims to provide an overview of microfluidic biosensor-based devices for cancer detection and high-throughput chemotherapeutic drug screening. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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IITH Creators:

IITH Creators	ORCiD
Rath, Subha Narayan	https://orcid.org/0000-0002-3414-2328

Item Type:

Book Section

Additional Information:

Acknowledgments This work was supported by the Council of Scientific & Industrial Research (CSIR), Government of India. The authors also like to acknowledge Mr. Dulam Praveen Kumar for providing an oversight on the biosensor part.

Uncontrolled Keywords:

Biomarkers; Biosensors; Breast cancer; In vitro 3D cancer models; Microfluidics; Therapeutic drug monitoring

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

14 Oct 2022 11:34

Last Modified:

14 Oct 2022 11:34