A facile one-pot protocol for the synthesis of tetrazolyl-tetrahydroisoquinolines via novel domino intramolecular cyclization/Ugi-azide sequence

Shinde, A H and Archith, N and MaliPatel, Srilaxmi and D S, Sharada (2014) A facile one-pot protocol for the synthesis of tetrazolyl-tetrahydroisoquinolines via novel domino intramolecular cyclization/Ugi-azide sequence. Tetrahedron Letters, 55 (50). pp. 6821-6826. ISSN 0040-4039

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Abstract

A facile one-pot, four-component domino reaction between 2-(2-bromoethyl)benzaldehyde, isocyanide, amine, and azide for the synthesis of tetrazolyl-tetrahydroisoquinoline derivatives has been developed. The reaction sequence involves intramolecular replacement of halide by iminium nitrogen followed by Ugi-azide reaction. The reaction is catalyst/additive free and takes place under ambient conditions with short reaction times to furnish products in good to excellent yields.

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IITH Creators:	IITH Creators ORCiD D S, Sharada UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	One-pot transformation; Tetrahydroisoquinoline; Tetrazole; Ugi-azide
Subjects:	?? sub5.8 ??
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	02 Dec 2014 04:23
Last Modified:	01 Apr 2019 09:12
URI:	http://raiithold.iith.ac.in/id/eprint/1093
Publisher URL:	http://dx.doi.org/10.1016/j.tetlet.2014.10.076
OA policy:	http://www.sherpa.ac.uk/romeo/issn/0040-4039/
Related URLs:	Google Scholar

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