Sweetcorn husk derived porous carbon with inherent silica for ultrasensitive detection of ovarian cancer in blood plasma

Pandey, Ullas and Rani, Malothu Usha and Deshpande, Atul Suresh and Singh, Shiv Govind and et al, . (2021) Sweetcorn husk derived porous carbon with inherent silica for ultrasensitive detection of ovarian cancer in blood plasma. Electrochimica Acta, 397. pp. 1-11. ISSN 0013-4686

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Abstract

Ovarian cancer is the foremost cause of death in women in the category of gynaecological malignancy. Fostering a high survival rate requires early prognosis and therefore needs ultrasensitive detection of a biomarker such as fibronectin, a glycoprotein in the extracellular matrix having a high prognostic value for ovarian cancer. Thus, such an application needs a cost-effective sensing material that possesses a high surface to volume ratio, good conductivity, and strong affinity towards biomolecules. Smartly engineered bio-wastes have shown notable potential in biosensors due to their innate biocompatibility albeit seldom utilized due to poor biomolecular interaction (sensitivity). In this work, a novel biosensor, based on sweet corn husk (bio-waste) derived porous carbon is demonstrated for a label-free ultra-detection of fibronectin protein. The reported porous carbon has high significance owing to high specific surface area (500 m2 g−1), excellent conductivity, and high affinity toward biomolecules due to the inherent presence of silica on the carbon surface. The announced biosensor presents a broad range (100 fg mL−1–10 μg mL−1) of detection with a sterling sensitivity (124.5 (KΩ/µg mL−1)/cm2) and a LOD of 129 fg mL−1. Further, it shows excellent selectivity, interference resistance response, reproducibility, high linearity and good stability, hence exhibiting a towering potential for real sample tests. © 2021

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IITH Creators:

IITH Creators	ORCiD
Deshpande, Atul Suresh	https://orcid.org/0000-0003-0874-9502
Singh, Shiv Govind	http://orcid.org/0000-0001-7319-879X

Item Type:

Article

Additional Information:

The authors acknowledge the Department of Science & Technology (DST) and ESIC Medical College & Hospital, Sanathnagar, Hyderabad for funding research and providing human blood plasma samples.

Uncontrolled Keywords:

Biosensor; Cornhusk-derived carbon; Fibronectin; Ovarian cancer

Subjects:

Electrical Engineering
Materials Engineering > Materials engineering

Divisions:

Department of Electrical Engineering
Department of Material Science Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

01 Oct 2022 10:25

Last Modified:

01 Oct 2022 10:25