Cancer cell membrane cloaked nanocarriers: A biomimetic approach towards cancer theranostics

Patra, Paloma and Rengan, Aravind Kumar (2022) Cancer cell membrane cloaked nanocarriers: A biomimetic approach towards cancer theranostics. Elsevier Ltd.

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Abstract

In physiological systems, nanoparticles (NPs) disguised within cell membranes constitute unique biomimetic platforms which can imitate several membrane functionalities of the source cells from where they are isolated. Cell membrane cloaked NPs have been investigated in studies encompassing a diverse array of membranes originating from cancer cells, immune cells, red blood cells and macrophages. Cancer cell membrane-cloaked nanocarriers (CM NCs), that have the ability to transport therapeutics / diagnostics right within the tumour cells, are receiving increased attention. CM NCs combine bioactive cell surface adhesioncomponents with additional proteins to provide longer systemic circulation and cell-specific homing, resulting in increased intra-tumoral invasion and tumor-specific NC localization. As a consequence, these CM NCs are indeed being explored for a variety of applications, as well as in cancer theranostics. The crucial processes and difficulties involving the fabrication and characterization of CM NCs have been described in this review. The homologous binding mechanism of CM NCs investigated for effective tumour targeting, have been highlighted and the merits and drawbacks of existing pre-clinical applications of CM NCs for cancer theranostics are discussed. © 2022 Elsevier Ltd

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Other

Additional Information:

The authors would like to acknowledge SERB-CRG ( CRG/2020/005069 ), ICMR (No. 35/1/2020-GIA/Nano/BMS ), DST-AMT ( DST/TDT/AMT/2017/227 ), ICMR-CoE and SOCH ( IITH/BME/SOCH3 ) grants for supporting this study. The author PP would like to gratefully acknowledge MoE-PMRF (ID 2001697) for funding her fellowship. The graphical abstract and schematic illustrations were prepared using Biorender.com.

Uncontrolled Keywords:

Biomimetic nanocarriers; Cancer cell membranes; Drug delivery; Homotypic adhesion; Theranostics

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

13 Sep 2022 11:07

Last Modified:

13 Sep 2022 11:07