Palladium-Catalyzed Distal m-C–H Functionalization of Arylacetic Acid Derivatives

Srinivas, Dasari and Satyanarayana, G. (2021) Palladium-Catalyzed Distal m-C–H Functionalization of Arylacetic Acid Derivatives. Organic Letters, 23 (19). pp. 7353-7358. ISSN 1523-7060

Text
Organic_Letters.pdf - Published Version
Restricted to Registered users only
Download (1MB) | Request a copy

Abstract

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol). © 2021 American Chemical Society.

[error in script]

IITH Creators:

IITH Creators	ORCiD
Satyanarayana, G.	UNSPECIFIED

Item Type:

Article

Additional Information:

We greatly acknowledge financial support from the DST-SERB (Department of Science and Technology, Science and Engineering Research Board, Grant EMR/2017/005312), New Delhi. D.S. thanks the DST-SERB (EMR/2017/005312) for providing a Fellowship.

Uncontrolled Keywords:

m-C-H olefination , phenylacetic acids , palladium catalysis.

Subjects:

Chemistry

Divisions:

Department of Chemistry

Depositing User:

. LibTrainee 2021

Date Deposited:

07 Sep 2022 14:21

Last Modified:

07 Sep 2022 14:21