A chemoselective oxidation of monosubstituted ethylene glycol: Facile synthesis of optically active α-hydroxy acids

Chinthapally, K and Baskaran, S (2014) A chemoselective oxidation of monosubstituted ethylene glycol: Facile synthesis of optically active α-hydroxy acids. Organic and Biomolecular Chemistry, 12 (25). pp. 4305-4308. ISSN 1477-0520

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Abstract

A mild and efficient method for the synthesis of optically active α-hydroxy acids through chemoselective oxidation of monosubstituted ethylene glycols using the TEMPO-NaOCl reagent system is described. It is evident from our studies that the solvent, pH and reaction temperature are very crucial for the success of this oxidation. The versatility of this method has been demonstrated with a variety of aliphatic, aromatic and carbohydrate substrates bearing various functional groups.

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IITH Creators:

IITH Creators	ORCiD

Item Type:

Article

Uncontrolled Keywords:

Carboxylic acids; Ethylene glycol; Functional groups; Polyols Chemoselective oxidation; Facile synthesis; Hydroxy acids; Optically Active; Reaction temperature; Reagent systems

Subjects:

?? sub5.8 ??

Divisions:

Department of Chemistry

Depositing User:

Team Library

Date Deposited:

03 Dec 2014 10:02

Last Modified:

03 Dec 2014 10:02

URI:

http://raiithold.iith.ac.in/id/eprint/1039