In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors

Baseeruddin Alvi, Syed and P S, Rajalakshmi and Begum, Nazia and Jogdand, Anil Bankati and Veeresh, Bantal and Rengan, Aravind Kumar (2021) In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors. ACS Applied Materials & Interfaces, 13 (47). pp. 55862-55878. ISSN 1944-8244

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Abstract

Metastasis is one of the predisposing factors for cancer-related mortalities worldwide. Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of achieving complete remission. Antibody-based therapeutic modalities are capable of targeting tumors that are confined to a particular location but are ineffective in targeting distant secondary tumors. In the current study, we have developed a smart nano-transforming hydrogel (NTG) that transforms in situ to polymeric nanoparticles (PA NPs) of 100-150 nm when injected subcutaneously. These nanoparticles targeted the primary and secondary metastatic tumors for up to ∼5 and ∼3 days, respectively. The in situ-formed PA NPs also demonstrated a pH-responsive drug release resulting in about ∼80% release within 100 h at 5.8 pH. When tested in vivo, substantial inhibition of lung metastases was observed compared to chemotherapy, thus demonstrating the efficiency of nanotransforming hydrogels in targeting and inhibiting primary and secondary metastatic tumors. © 2021 American Chemical Society.

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IITH Creators:
IITH CreatorsORCiD
Rengan, Aravind KumarUNSPECIFIED
Item Type: Article
Additional Information: The authors would like to acknowledge the following funding agencies: DBT-IYBA (BT/09/IYBA/2015/14), MHRD IMPRINT 1 and 2 (4291, 00275), DST INSPIRE (INSPIRE/04/2015/00037), (DST/TDT/AMT/2017/227), and Vasudha Foundation, CRG/2020/005069. The authors would like to acknowledge Lipoid Germany and VAV Pvt Ltd for providing a generous sample of lipid. Author S.B.A. would like to thank the CSIR for SRF as financial support (09/1001(0044)/2019-EMR-1), and RJ would like to acknowledge the UGC (938/(OBC) (CSIR-UGC NET Dec.2016)) for financial support.
Uncontrolled Keywords: hydrogel; melanoma; metastasis; nanoparticles; passive targeting
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 29 Aug 2022 10:02
Last Modified: 29 Aug 2022 10:02
URI: http://raiithold.iith.ac.in/id/eprint/10322
Publisher URL: http://doi.org/10.1021/acsami.1c17054
OA policy: https://v2.sherpa.ac.uk/id/publication/7761
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