In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors

Baseeruddin Alvi, Syed and P S, Rajalakshmi and Begum, Nazia and Jogdand, Anil Bankati and Veeresh, Bantal and Rengan, Aravind Kumar (2021) In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors. ACS Applied Materials & Interfaces, 13 (47). pp. 55862-55878. ISSN 1944-8244

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Abstract

Metastasis is one of the predisposing factors for cancer-related mortalities worldwide. Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of achieving complete remission. Antibody-based therapeutic modalities are capable of targeting tumors that are confined to a particular location but are ineffective in targeting distant secondary tumors. In the current study, we have developed a smart nano-transforming hydrogel (NTG) that transforms in situ to polymeric nanoparticles (PA NPs) of 100-150 nm when injected subcutaneously. These nanoparticles targeted the primary and secondary metastatic tumors for up to ∼5 and ∼3 days, respectively. The in situ-formed PA NPs also demonstrated a pH-responsive drug release resulting in about ∼80% release within 100 h at 5.8 pH. When tested in vivo, substantial inhibition of lung metastases was observed compared to chemotherapy, thus demonstrating the efficiency of nanotransforming hydrogels in targeting and inhibiting primary and secondary metastatic tumors. © 2021 American Chemical Society.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	UNSPECIFIED

Item Type:

Article

Additional Information:

The authors would like to acknowledge the following funding agencies: DBT-IYBA (BT/09/IYBA/2015/14), MHRD IMPRINT 1 and 2 (4291, 00275), DST INSPIRE (INSPIRE/04/2015/00037), (DST/TDT/AMT/2017/227), and Vasudha Foundation, CRG/2020/005069. The authors would like to acknowledge Lipoid Germany and VAV Pvt Ltd for providing a generous sample of lipid. Author S.B.A. would like to thank the CSIR for SRF as financial support (09/1001(0044)/2019-EMR-1), and RJ would like to acknowledge the UGC (938/(OBC) (CSIR-UGC NET Dec.2016)) for financial support.

Uncontrolled Keywords:

hydrogel; melanoma; metastasis; nanoparticles; passive targeting

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

29 Aug 2022 10:02

Last Modified:

29 Aug 2022 10:02