Hepatogenic differentiation of adipose-derived mesenchymal stem cells directed by topographical cues: a proof of concept study

Sasikumar, Shyama and Chameettachal, Shibu and Kingshott, Peter and Cromer, Brett and Pati, Falguni (2022) Hepatogenic differentiation of adipose-derived mesenchymal stem cells directed by topographical cues: a proof of concept study. Proceedings of the Indian National Science Academy. ISSN 0370-0046

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Abstract

Topography and roughness are key features that can direct the behavior of cells. Here, we have developed a surface pattern comparable to the features and roughness present in the native liver tissue by virtue of the liver extracellular matrix. This study used polydimethylsiloxane to get an imprint of the topographical pattern of the native liver and used this imprint as a template to guide the differentiation of adipose-derived mesenchymal stem cells. The results showed a similar gene and protein expression profile to that of hepatocytes, showing potential in the field of scaffold development for tissue engineering applications. © 2022, Indian National Science Academy.

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IITH Creators:

IITH Creators	ORCiD
Pati, Falguni	http://orcid.org/0000-0002-3588-1800

Item Type:

Article

Additional Information:

The authors would like to acknowledge Ramalingaswami Research Fellowship from the Department of Biotechnology, Govt. of India (BT/HRD/35/02/2006). In addition, SS would like to thank the Department of Biotechnology, Govt. of India for the DBT-JRF fellowship and the Swinburne University of Technology, Melbourne, Australia, for funding the Swinburne University Postgraduate Research Award (SUPRA).

Uncontrolled Keywords:

Liver tissue engineering; Roughness; Scaffolds; Stem cell differentiation; Topography

Subjects:

Others > Biotechnology
Biomedical Engineering
Chemistry
Materials Engineering > Materials engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

16 Aug 2022 09:46

Last Modified:

16 Aug 2022 09:46