Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research

Puppala, Alekhya and Rankawat, Sourbh and Ray, Sandipan (2021) Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research. Current Drug Metabolism, 22 (13). pp. 998-1008. ISSN 1389-2002

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Abstract

Background: Intrinsic rhythms in host and cancer cells play an imperative role in tumorigenesis and anticancer therapy. Circadian medicine in cancer is principally reliant on the control of growth and development of cancer cells or tissues by targeting the molecular clock and implementing time-of-day-based anticancer treatments for therapeutic improvements. In recent years, based on extensive high-throughput studies, we witnessed the arrival of several drugs and drug-like compounds that can modulate circadian timekeeping for therapeutic gain in cancer man-agement. Objective: This perspective article intends to illustrate the current trends in circadian medicine in cancer, focusing on clock-modulating pharmacological compounds and circadian regulation of anticancer drug metabolism and efficacy. Scope and Approach: Considering the critical roles of the circadian clock in metabolism, cell signaling, and apopto-sis, chronopharmacology research is exceedingly enlightening for understanding cancer biology and improving anticancer therapeutics. In addition to reviewing the relevant literature, we investigated the rhythmic expression of molecular targets for many anticancer drugs frequently used to treat different cancer types. Key Findings and Conclusion: There are adequate empirical pieces of evidence supporting circadian regulation of drug metabolism, transport, and detoxification. Administration of anticancer drugs at specific dosing times can im-prove their effectiveness and reduce the toxic effects. Moreover, pharmacological modulators of the circadian clock could be used for targeted anticancer therapeutics such as boosting circadian rhythms in the host can markedly reduce the growth and viability of tumors. All in all, precision chronomedicine can offer multiple advantages over conventional anticancer therapy. © 2021 Bentham Science Publishers.

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IITH Creators:

IITH Creators	ORCiD
Ray, Sandipan	https://orcid.org/0000-0002-9960-5768

Item Type:

Article

Additional Information:

This study has been funded by the Indian Institute of Technology, Hyderabad (SG-94-2021).

Uncontrolled Keywords:

Anticancer therapeutics; Cancer; Chronomedicine; Circadian rhythms; Clock-modulating compounds; Dosing time-dependency; Drug metabolism; Metabolic oscillators

Subjects:

Others > Biotechnology

Divisions:

Department of Biotechnology

Depositing User:

. LibTrainee 2021

Date Deposited:

08 Aug 2022 09:41

Last Modified:

08 Aug 2022 09:41

URI:

http://raiithold.iith.ac.in/id/eprint/10146